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KMID : 0377519850100030319
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Chung-Ang Journal of Medicine
1985 Volume.10 No. 3 p.319 ~ p.325
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The Effect of Combination of Radiation with 5-Fluorouracil on Mouse Jejunal Crypt Cells
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Abstract
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The interaction of radiaticn and 5-Fluorouracil(3-FU) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150mg/kg of 5-FU was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-FU was given 15 minutes before irradiation than giving it 6 hours after irradiation.
The mean lethal doses(Do) of each of irradiation alone group, 5-FU injection group of 15 minttes preceding irradiation, and 5-FU injection group of 6 hours postirradiation were, 135, 135, and ill rad respectively. The dose effect. factor of each of 5-FU injection groups of 15 minutes preceding irradiation and of 6 hours post irradiation were 1. 13 and 1. 27.
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KEYWORD
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